A comparison of the two medications reveals that Phenergan is more effective in emergency situations, whereas Compazine is better suited for ongoing management of nausea and vomiting In the comparison of Phenergan vs Compazine , it's essential to consider your individual needs and circumstances Compare prices and print coupons for Phenergan and other drugs at CVS, Walgreens, and other pharmacies Prices start at $2 49 Compare Phenergan (promethazine) prices available at international online pharmacies with local U S pharmacy coupon prices The lowest price on PharmacyChecker com for Phenergan (promethazine) 5mg 5ml is $0 29 per ml for 200 mls at PharmacyChecker-accredited online pharmacies Compare Compazine vs Phenergan head-to-head with other drugs for uses, ratings, cost, side effects and interactions May 13, 2025 · Compare prescription drug prices and find coupons at more than 70,000 US pharmacies Save up to 80% instantly! Promethazine ( Phenergan ) and prochlorperazine (Compro) are both prescription medications used to treat nausea and vomiting, but they have some key differences Promethazine is an antihistamine that also blocks dopamine and acetylcholine, making it useful for treating allergies, motion sickness, and as a sedative before surgery Compare Compazine and Phenergan side effects, costs and risks for treating Nausea